Articles

  1. Inside UVA OnLine: March 26- April 8, 2004,
    Vol 34, Issue 6: Davis Parker’s Magnum Opus

  2. Parker WD Jr, Parks JK, Swerdlow RH.
    Complex I deficiency in Parkinson's disease frontal cortex.
    Brain Res. 2008 Jan 16;1189:215-8. Epub 2007 Nov 1. PMID: 18061150 [PubMed - indexed for MEDLINE]

  3. McAllister J, Ghosh S, Berry D, Park M, Sadeghi S, Wang KX, Parker WD, Swerdlow RH.
    Effects of memantine on mitochondrial function.
    Biochem Pharmacol. 2008 Feb 15;75(4):956-64. Epub 2007 Oct 23. PMID: 18053965 [PubMed - indexed for MEDLINE]

  4. Smigrodzki R, Goertzel B, Pennachin C, Coelho L, Prosdocimi F, Parker WD Jr.
    Genetic algorithm for analysis of mutations in Parkinson's disease.
    Artif Intell Med. 2005 Nov;35(3):227-41. Epub 2005 Oct 3. PMID: 16207526 [PubMed - indexed for MEDLINE]

  5. Parker WD Jr, Parks JK.
    Mitochondrial ND5 mutations in idiopathic Parkinson's disease.
    Biochem Biophys Res Commun. 2005 Jan 21;326(3):667-9. PMID: 15596151 [PubMed - indexed for MEDLINE]

  6. Smigrodzki R, Parks J, Parker WD.
    High frequency of mitochondrial complex I mutations in Parkinson's disease and aging.
    Neurobiol Aging. 2004 Nov-Dec;25(10):1273-81. PMID: 15465623 [PubMed - indexed for MEDLINE

  7. Trimmer PA, Borland MK, Keeney PM, Bennett JP Jr, Parker WD Jr.
    Parkinson's disease transgenic mitochondrial cybrids generate Lewy inclusion bodies.
    J Neurochem. 2004 Feb;88(4):800-12. PMID: 14756800 [PubMed - indexed for MEDLINE]

  8. Trimmer PA, Borland MK, Keeney PM, Bennett JP Jr, Parker WD Jr.
    Parkinson's disease transgenic mitochondrial cybrids generate Lewy inclusion bodies.
    J Neurochem. 2004 Feb;88(4):800-12. PMID: 14756800 [PubMed - indexed for MEDLINE]

  9. Swerdlow RH, Parks JK, Pattee G, Parker WD Jr.
    Role of mitochondria in amyotrophic lateral sclerosis.
    Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Jun;1(3):185-90. Review. PMID: 11464951 [PubMed - indexed for MEDLINE]

  10. Swerdlow RH, Parks JK, Cassarino DS, Binder DR, Bennett JP Jr, Di Iorio G, Golbe LI, Parker WD Jr.
    Biochemical analysis of cybrids expressing mitochondrial DNA from Contursi kindred Parkinson's subjects.
    Exp Neurol. 2001 Jun;169(2):479-85.PMID: 11358461 [PubMed - indexed for MEDLINE]

  11. Swerdlow RH, Parker WD, Currie LJ, Bennett JP, Harrison MB, Trugman JM, Wooten GF.
    Gender ratio differences between Parkinson's disease patients and their affected relatives.
    Parkinsonism Relat Disord. 2001 Apr;7(2):129-133. PMID: 11248594 [PubMed - as supplied by publisher]

  12. Parks JK, Smith TS, Trimmer PA, Bennett JP Jr, Parker WD Jr.
    Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondria permeability transition in vitro.
    J Neurochem. 2001 Feb;76(4):1050-6. PMID: 11181824 [PubMed - indexed for MEDLINE]

  13. Swerdlow RH, Golbe LI, Parks JK, Cassarino DS, Binder DR, Grawey AE, Litvan I, Bennett JP Jr, Wooten GF, Parker WD. Mitochondrial dysfunction in cybrid lines expressing mitochondrial genes from patients with progressive supranuclear palsy. J Neurochem. 2000 Oct;75(4):1681-4. PMID: 10987850 [PubMed - indexed for MEDLINE]

  14. Veech GA, Dennis J, Keeney PM, Fall CP, Swerdlow RH, Parker WD Jr, Bennett JP Jr.
    Disrupted mitochondrial electron transport function increases expression of anti- apoptotic bcl-2 and bcl-X(L) proteins in SH-SY5Y neuroblastoma and in Parkinson disease cybrid cells through oxidative stress.
    J Neurosci Res. 2000 Sep 15;61(6):693-700. PMID: 10972966 [PubMed - indexed for MEDLINE]

  15. Khan SM, Cassarino DS, Abramova NN, Keeney PM, Borland MK, Trimmer PA, Krebs CT, Bennett JC, Parks JK, Swerdlow RH, Parker WD Jr, Bennett JP Jr.
    Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways.
    Ann Neurol. 2000 Aug;48(2):148-55. PMID: 10939564 [PubMed - indexed for MEDLINE]

  16. Cassarino DS, Halvorsen EM, Swerdlow RH, Abramova NN, Parker WD Jr, Sturgill TW, Bennett JP Jr.
    Interaction among mitochondria, mitogen-activated protein kinases, and nuclear factor- kappaB in cellular models of Parkinson's disease.
    J Neurochem. 2000 Apr;74(4):1384-92. PMID: 10737593 [PubMed - indexed for MEDLINE]

  17. Trimmer PA, Swerdlow RH, Parks JK, Keeney P, Bennett JP Jr, Miller SW, Davis RE, Parker WD Jr.
    Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines.
    Exp Neurol. 2000 Mar;162(1):37-50. PMID: 10716887 [PubMed - indexed for MEDLINE]

  18. Caldwell SH, Swerdlow RH, Khan EM, Iezzoni JC, Hespenheide EE, Parks JK, Parker WD Jr.
    Mitochondrial abnormalities in non-alcoholic steatohepatitis.
    J Hepatol. 1999 Sep;31(3):430-4. PMID: 10488700 [PubMed - indexed for MEDLINE]

  19. Swerdlow RH, Parks JK, Cassarino DS, Shilling AT, Bennett JP Jr, Harrison MB, Parker WD Jr.
    Characterization of cybrid cell lines containing mtDNA from Huntington's disease patients.
    Biochem Biophys Res Commun. 1999 Aug 11;261(3):701-4. PMID: 10441489 [PubMed - indexed for MEDLINE]

  20. Cassarino DS, Parks JK, Parker WD Jr, Bennett JP Jr.
    The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism.
    Biochim Biophys Acta. 1999 Jan 6;1453(1):49-62. PMID: 9989245 [PubMed - indexed for MEDLINE]

  21. Swerdlow RH, Parks JK, Davis JN 2nd, Cassarino DS, Trimmer PA, Currie LJ, Dougherty J, Bridges WS, Bennett JP Jr, Wooten GF, Parker WD.
    Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family.
    Ann Neurol. 1998 Dec;44(6):873-81. PMID: 9851431 [PubMed - indexed for MEDLINE]

  22. Joffe GT, Parks JK, Parker WD Jr.
    Secondary inhibition of 2-ketoglutarate dehydrogenase complex by MPTP.
    Neuroreport. 1998 Aug 24;9(12):2781-3. PMID: 9760120 [PubMed - indexed for MEDLINE]

  23. Cassarino DS, Swerdlow RH, Parks JK, Parker WD Jr, Bennett JP Jr.
    Cyclosporin A increases resting mitochondrial membrane potential in SY5Y cells and reverses the depressed mitochondrial membrane potential of Alzheimer's disease cybrids.
    Biochem Biophys Res Commun. 1998 Jul 9;248(1):168-73. PMID: 9675105 [PubMed - indexed for MEDLINE]

  24. Parker WD Jr, Swerdlow RH.
    Mitochondrial dysfunction in idiopathic Parkinson disease.
    Am J Hum Genet. 1998 Apr;62(4):758-62. Review. PMID: 9529370 [PubMed - indexed for MEDLINE]

  25. Davis JN 2nd, Parker WD Jr.
    Evidence that two reports of mtDNA cytochrome c oxidase "mutations" in Alzheimer's disease are based on nDNA pseudogenes of recent evolutionary origin.
    Biochem Biophys Res Commun. 1998 Mar 27;244(3):877-83. PMID: 9535760 [PubMed - indexed for MEDLINE]

  26. Cassarino DS, Fall CP, Swerdlow RH, Smith TS, Halvorsen EM, Miller SW, Parks JP, Parker WD Jr, Bennett JP Jr.
    Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease.
    Biochim Biophys Acta. 1997 Nov 28;1362(1):77-86. PMID: 9434102 [PubMed - indexed for MEDLINE]

  27. Swerdlow RH, Parks JK, Cassarino DS, Maguire DJ, Maguire RS, Bennett JP Jr, Davis RE, Parker WD Jr.
    Cybrids in Alzheimer's disease: a cellular model of the disease?
    Neurology. 1997 Oct;49(4):918-25. PMID: 9339668 [PubMed - indexed for MEDLINE]

  28. Sheehan JP, Swerdlow RH, Miller SW, Davis RE, Parks JK, Parker WD, Tuttle JB.
    Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease.
    J Neurosci. 1997 Jun 15;17(12):4612-22. PMID: 9169522 [PubMed - indexed for MEDLINE]

  29. Sheehan JP, Swerdlow RH, Parker WD, Miller SW, Davis RE, Tuttle JB.
    Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease.
    J Neurochem. 1997 Mar;68(3):1221-33. PMID: 9048769 [PubMed - indexed for MEDLINE]

  30. Wooten GF, Currie LJ, Bennett JP, Harrison MB, Trugman JM, Parker WD Jr.
    Maternal inheritance in Parkinson's disease.
    Ann Neurol. 1997 Feb;41(2):265-8. PMID: 9029076 [PubMed - indexed for MEDLINE]

  31. Swerdlow RH, Parks JK, Miller SW, Tuttle JB, Trimmer PA, Sheehan JP, Bennett JP Jr, Davis RE, Parker WD Jr.
    Origin and functional consequences of the complex I defect in Parkinson's disease.
    Ann Neurol. 1996 Oct;40(4):663-71. PMID: 8871587 [PubMed - indexed for MEDLINE]

  32. Parker WD Jr, Parks JK.
    Cytochrome c oxidase in Alzheimer's disease brain: purification and characterization.
    Neurology. 1995 Mar;45(3 Pt 1):482-6. PMID: 7898701 [PubMed - indexed for MEDLINE]

  33. Smith TS, Swerdlow RH, Parker WD Jr, Bennett JP Jr.
    Reduction of MPP(+)-induced hydroxyl radical formation and nigrostriatal MPTP toxicity by inhibiting nitric oxide synthase.
    Neuroreport. 1994 Dec 20;5(18):2598-600. PMID: 7535121 [PubMed - indexed for MEDLINE]

  34. Smith TS, Parker WD Jr, Bennett JP Jr.
    L-dopa increases nigral production of hydroxyl radicals in vivo: potential L-dopa toxicity?
    Neuroreport. 1994 Apr 14;5(8):1009-11. PMID: 8061280 [PubMed - indexed for MEDLINE]

  35. Hammer B, Parker WD Jr, Bennett JP Jr.
    NMDA receptors increase OH radicals in vivo by using nitric oxide synthase and protein kinase C.
    Neuroreport. 1993 Oct 25;5(1):72-4. PMID: 7506590 [PubMed - indexed for MEDLINE]

  36. Parker WD, Parks JK, DeMasters BK, Filley CM:
    Electron transport chain defects in Alzheimer's Disease brain.
    Neurology 44:1090-1096, 1994

  37. Parker WD, Parks JK, DeMasters BK, Filley CM:
    Electron transport chain defects in Alzheimer's Disease brain.
    Neurology 44:1090-1096, 1994

  38. Parker WD, Oley CA, Parks JK:
    Leber's hereditary optic neuropathy: Deficient NADH:coenzyme Q oxidoreductase activity.
    New England J Med, 320:1331-1333, 1989

  39. Parker WD, Boyson SJ, Parks JK:
    Electron transport chain abnormalities in idiopathic Parkinson's disease.
    Annals Neurol 26:719-723, 1989.

  40. Bindhoff LA, Birch-Machin M, Cartlidge NEF, Parker WD, Turnbull DM.
    Mitochondrial function in Parkinson's disease.
    Lancet 2:49, 1989

  41. Luder AS, Parks J, Parker WD:
    Use of human blood platelets in the study of mitochondrial biochemical and genetic disorders.
    Annual meeting - Israel Association of Human Genetics, 1989

  42. Parker WD, Filley CM, Parks JK:
    Cytochome oxidase deficiency in Alzheimer's disease.
    Neurology, 40:1302-1303, 1990.

  43. Parker WD, Boyson SJ, Parks JK:
    Evidence for a defect in NADH:ubiquinone oxidoreductase (complex I) in Huntington's disease.
    Neurology, 40:1231-1233, 1990

  44. Parker WD:
    Sporadic neurologic disease and the electron transport chain: A hypothesis. Chapter 5. In: Pascuzzi R, ed: New Developments in Neuromuscular disease. Indiana University Printing Services, Bloomington, Indiana, 1990:59-64.

  45. Bindhoff LA, Birch-Machen MA, Cartlidge NEF, Parker WD, Turnbull DM:
    Respiratory chain abnormalities in skeletal muscle from patients with Parkinson's disease.
    J Neurol Sci, 104:203-208, 1991.

  46. Parker WD:
    Preclinical detection of Parkinson's disease:
    Biochemical Approaches. Neurology, 41 (suppl 2):34-37, 1991.

  47. Burkhardt C, Kelly JA, Lim Y, Filley CM, Parker WD:
    MPTP-like toxicity of neuroleptic medications.
    Annals of Neurology 33:512-517, 1993

  48. Parker WD:
    Cytochrome oxidase deficiency and Alzheimer's disease.
    Ann NY Acad Sci 640:59-64, 1991

  49. Bennett MC, Diamond DM, Stryker SL, Parks JK, Parker WD:
    Cytochrome oxidase inhibition: A novel animal model of Alzheimer's disesease.
    J Geriatr Psychiatr Neurol 5:93-101, 1992

  50. Bennett MC, Diamond DM, Parker, Jr, WD, Stryker SL, Rose GM:
    Inhibition of cytochrome oxidase impairs learning and hippocampal plasticity:
    A novel animal model

  51. Parker WD, Mahr NJ, Hughes D, Filley CM, Cullum CM:
    Reduced Platelet Cytochrome Oxidase Activity in Alzheimer's Disease.
    Neurology 44:1086-1090, 1994.

  52. Parker WD, Frerman F, Haas R, Parks JK:
    Myxothiazol resistance in human mitochondria.
    Biochim Biophys Acta 936:133-138, 1988